STUDIES ON THE REACTION BETWEEN PYRIDINE NUCLEOTIDES AND MERCURY COMPOUNDS IN ARTIFICIAL INTRACELLULAR AND EXTRACELLULAR FLUIDS

1 January 1979

journal article
Published by Japanese Society of Toxicology in The Journal of Toxicological Sciences

Vol. 4 (4) , 417-425
https://doi.org/10.2131/jts.4.417

Abstract

The strong complex formations of pyridine nucleotides with mercury compounds were demonstrated in artificial intracellular fluid containing oxianions (HPO42-, HCO3-), while those in artificial extracellular fluid were considerably weaker. Dissociation constants (K) of the complexes of [MC.NADP], [MC.NADPH], [MC.NAD], [MC.NADH], [MC.adenine], and [MC.nicotinamide mononucleotide] were found to be 1.0 x 10(-4), 2.6 x 10(-5), 1.2 x 10(-4), 2.9 x 10(-5), 7.2 x 10(-6), and 3.8 x 10(-3), respectively in phosphate buffer (43 mM, pH 8.0).

Keywords

MERCURY COMPOUNDS
PYRIDINE NUCLEOTIDES
EXTRACELLULAR FLUIDS
ARTIFICIAL INTRACELLULAR

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