ANTIFUNGAL ACTIVITY OF ISOTHIOCYANATES AND RELATED COMPOUNDS .I. NATURALLY OCCURING ISOTHIOCYANATES AND THEIR ANALOGUES
- 1 January 1967
- journal article
- research article
- Vol. 15 (4) , 701-+
Abstract
Data are presented concerning the antifungal activity of 11 natural isothiocyanates and 27 synthetized analogues in Aspergillus niger, Penicillium cyclopium, and Rhizopus oryzae, as well as an additional 13 saprophytic and parasitic fungi. A remarkable antifungal activity was observed in some analogues of benzylisothiocyanate and [beta]-phenylethylisothiocyanate. The latter-mentioned compounds have not been described previously. In the group of benzylisothiocyanates, a correlation, which was inversely proportional, was detected between ED100 values for A. niger and R. oryzae and the corresponding molar solubilities of compounds in water. In contradistinction, no relationship was observed between antifungal activity and chemical reactivity of investigated derivatives.This publication has 4 references indexed in Scilit:
- Antiworm activity of some natural and synthetic compounds. I. Effect of aliphatic and mononuclear aromatic isothiocyanates on Turbatrix aceti.1965
- Cancerostatic action of beta-naphtylisothiocyanate on skin carcinoma of mice (Preliminary report).1961
- [New and shortened therapy of superficial trichophytosis of the smooth skin with p-bromophenylisothiocyanate (PBFI)].1959
- Cancerostatic action of beta-naphtylisothiocyanate.1958