Production and Characterization of Monoclonal Antibodies Specific for Mycobacterium bovis
- 1 September 1988
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 134 (9) , 2599-2604
- https://doi.org/10.1099/00221287-134-9-2599
Abstract
Summary: A series of monoclonal antibodies (MAbs), specific for Mycobacterium bovis and BCG strains, were tested extensively for cross-reactivity to a wide range of mycobacterial species using ELISA, Western blotting and dot-blot analysis. The MAbs bound specifically to M. bovis and BCG and showed limited cross-reactivity with some strains of M. tuberculosis. All these MAbs recognized a 22 kDa protein previously termed MPB70, and by competitive ELISA analysis appeared to detect at least three M. bovis-specific determinants on the MPB70 molecule.This publication has 14 references indexed in Scilit:
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