Typical and atypical neuroleptics are potent antagonists at ?1-adrenoceptors of the dorsal lateral geniculate nucleus

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Abstract
The present electrophysiological studies examined the actions of neuroleptics at central α1adrenoceptors in the rat. In single-cell recording experiments, typical and atypical neuroleptics, when administered systemically or locally (iontophoresis and pressure ejection), were found to be potent antagonists of activating α1adrenoceptor responses in the dorsal lateral geniculate nucleus (dLGN). Doses of neuroleptics effective as antagonists at α1adrenoceptors had very weak effects as muscarinic receptors in the dLGN. Since doses of neuroleptics employed in the present study were within the clinical range, it appears likely that central α1adrenoceptors would be blocked during neuroleptic therapy in humans.

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