Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"
- 14 December 2007
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 318 (5857) , 1722
- https://doi.org/10.1126/science.1149590
Abstract
Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.Keywords
This publication has 15 references indexed in Scilit:
- Tumor Growth Need Not Be Driven by Rare Cancer Stem CellsScience, 2007
- Modeling the Initiation and Progression of Human Acute Leukemia in MiceScience, 2007
- Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem CellsCancer Research, 2006
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9Nature, 2006
- Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cellsNature, 2006
- MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitorsCancer Cell, 2004
- Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factorsLeukemia, 2003
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- A cell initiating human acute myeloid leukaemia after transplantation into SCID miceNature, 1994
- A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivoNature, 1963