Gastric Acid and Pepsin Secretion in Response to Modified Sham Feeding in Active and Inactive Duodenal Ulcer Disease

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Abstract
Gastric secretion of acid and pepsin were studied under basal conditions, in response to modified sham feeding (MSF) an in response to pentagastrin in 15 male controls and in 11 and 10 male patients with active and inactive duodenal ulcer disease, respectively. In general, patients with ulcer disease produced more acid and pepsin than controls. No differences between the 2 ulcer groups were found for basal and pentagastrin-stimulated secretions. The response patterns of MSF, however, were different in the 2 groups. After an early peak, acid and pepsin responses rapidly decreased, approaching basal level in patients with active duodenal ulcer and in controls. In patients with inactive disease, however, the decrease was less marked, and in some patients the secretion continued to increase for 60 min. When expressed as fractions of the responses to pentagastrin, the acid and pepsin responses during the 4th 15-min period were significantly greater in patients with inactive duodenal ulcer disease than in patients with active disease and in controls. The gastric response to vagal stimulation is different in patients with active and inactive duodenal ulcer disease.