Debromosceptrin, an Alkaloid from the Caribbean Sponge Agelas conifera
- 31 July 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (10) , 1302-1303
- https://doi.org/10.1021/np980129a
Abstract
As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas conifera collected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1−3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.Keywords
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