Prenatal diagnosis of chromosomal abnormalities from chorionic biopsy samples: Improved success rate using a modified direct method
- 1 September 1987
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 7 (7) , 461-469
- https://doi.org/10.1002/pd.1970070702
Abstract
Several methods for fetal chromosome analysis using chorionic biopsy samples were compared. A modified direct method for culturing villi was considered to be the method of choice and details are presented of 186 pregnancies tested prenatally. The success rate in obtaining a fetal karyotype with the direct method was 93 per cent. The fetal loss rate in the prenatal series was 4.3 per cent and congenital abnormalities in the babies already born did not differ from the expected incidence.Keywords
This publication has 8 references indexed in Scilit:
- SAFETY OF CHORIONIC VILLUS SAMPLINGThe Lancet, 1985
- First trimester fetal diagnosis of genetic disorders: clinical evaluation of 250 cases.Journal of Medical Genetics, 1985
- SPONTANEOUS FETAL LOSS RATE IN EARLY PREGNANCYThe Lancet, 1985
- Results of 180 First Trimester Direct Chromosome Studies in Chorionic VilliPublished by Springer Nature ,1985
- A collaborative study of the segregation of inherited chromosome structural rearrangements in 1356 prenatal diagnosesPrenatal Diagnosis, 1984
- Diagnostic application of first trimester trophoblast sampling in 100 pregnanciesHuman Genetics, 1984
- First-trimester diagnosis on chorionic villi obtained by direct vision techniqueHuman Genetics, 1984
- Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancyHuman Genetics, 1983