Effects of Pentostatin (2′ Deoxycoformycin), an Inhibitor of Adenosine Deaminase, on type II Collagen-Induced Arthritis in Rats

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Abstract
Pentostatin (2′-deoxycoformycin), a potent inhibitor of adenosine deaminase, was administered therapeutically to rats with type II collagen-induced arthritis and the effects on hind paw swelling, serum haptoglohin concentration, and anticollagen antibody titer determined. mily intraperitoneal administration of pentostatin at 10.0 or 1.0 mg/kg/day for three wecks produced significant enhancement of hind-paw swelling and elevation of serum haptoglobin. Continuous subcutaneous infusion of pentostatin at 1.0 or 0.1 mg/kg/day had the same effects. None of the dosing regimens had any effect on anticollagen antibody titer.