Resistance of Klebsiella and Enterobacter to the Penicillins

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Abstract
Klebsiella and Enterobacter resist penicillins because of intrinsic resistance (resistance of the individual organism), peni-cillinase activity, and mutations to increased resistance In Klebsiella strains, intrinsic resistances to benzylpemcillin and heta-cillin were similar In Enterobacter strains, intrinsic resistances were distinctly lower to hetacillin than to benzylpenicillin and were reduced by a subinhibitory concentration of dicloxacillin All strains had penicillin-B-lactamase activity which was usually inhibited by dicloxacillin Single step mutations to large increases in intrinsic resistance were common.