Intracellular Synthesis of Varicella-Zoster Virus
- 1 August 1992
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 166 (Supplement) , S7-S12
- https://doi.org/10.1093/infdis/166.supplement_1.s7
Abstract
Varicella-zoster virus, a reclusive α-herpesvirus, can be isolated and propagated in a limited number of human cell lines. Under in vitro conditions, the virus is strongly cell-associated and, therefore, difficult to recover in a truly cell-free state. The general replication cycle includes the three phases called immediate early, early, and late. An example of an early viral protein is a putative protein kinase called open reading frame (ORF) 47. An example of a late protein is the preponderant viral glycoprotein (ORF 68) designated VZV gpI.Keywords
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