Synthesis and Biological Evaluation of (±)-Epibatidine and the Congeners
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (05) , 343-344
- https://doi.org/10.1055/s-1994-22847
Abstract
A total synthesis of the non-opiate antinociceptive alkaloid (±)-epibatidine and its congeners is described, in which the key step is the reductive elimination of hydroxy function in 8a. The hydrogenolysis of 8a proceeded smoothly with retention of the configuration to afford 9a. Biological evaluation of these compounds is also included.Keywords
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