RELATIONSHIP BETWEEN TRANS-CEREBRAL PASSAGE OF TUMOR-CELLS AND BRAIN METASTASIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (1) , 65-71
Abstract
A quantitative study was done on transcerebral passage of tumor cells using Yoshida sarcoma and 6 strains of rat ascites hepatoma. Counting was done every second for 40 s. In relation to the results obtained, histological study was made on cerebral metastases of these tumor cells. Metastatic foci in the brain parenchyma, except the meninges and choroid plexus, were formed by island forming strains (AH-130, AH-272 and AH-7974) which showed comparatively low passage rate and not by single cell strains (Yoshida sarcoma, AH-7974F, AH-66F and AH-13) which showed comparatively high rates. There was a correlation between transcerebral passage rates and brain metastasis formation. The mechanisms of metastasis formation were discussed with special reference to arrest of tumor cells in blood vessels.