Felbamate Overdose Complicated by Massive Crystalluria and Acute Renal Failure
- 1 January 2000
- journal article
- case report
- Published by Taylor & Francis in Journal of Toxicology: Clinical Toxicology
- Vol. 38 (6) , 667-669
- https://doi.org/10.1081/clt-100102019
Abstract
We report a 20-year-old woman who developed altered mental status, massive crystalluria, and acute renal failure following an intentional overdose of felbamate and sodium valproate. Peak plasma concentrations of felbamate and sodium valproate were 200 microg/mL and 470 microg/mL, respectively. Macroscopic urinary crystals formed approximately 18 hours after ingestion and were identified by gas chromatography as containing felbamate. Renal ultrasound revealed unilateral hydronephrosis. Following parenteral hydration, the crystalluria and acute renal failure resolved and the patient recovered. The frequency and significance of crystalluria in felbamate intoxication is unknown.Keywords
This publication has 6 references indexed in Scilit:
- Crystalluria: a neglected aspect of urinary sediment analysisNephrology Dialysis Transplantation, 1996
- Felbamate overdose: A case report and discussion of a new antiepileptic drugPediatric Emergency Care, 1995
- The effect of felbamate on valproic acid dispositionClinical Pharmacology & Therapeutics, 1994
- Felbamate Pharmacology and Use in EpilepsyClinical Neuropharmacology, 1994
- Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome)New England Journal of Medicine, 1993
- Unusual Calcium Oxalate Crystals in Ethylene Glycol PoisoningClinical Toxicology, 1980