Cytotoxicity of a Perfluorocarbon Blood Substitute to Macrophages in Vitro
- 27 May 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4600) , 965-967
- https://doi.org/10.1126/science.6844922
Abstract
Murine macrophage and macrophage-depleted splenocyte cultures were incubated under ambient oxygen with a commercially available perfluorocarbon blood substitute. The perfluorocarbon preparation was found to be selectively cytotoxic to macrophages. This finding may be significant in view of the preliminary therapeutic usage of these preparations. In addition, perfluorocarbons may be useful as a means of selectively removing macrophages from tissue and organ cultures.This publication has 10 references indexed in Scilit:
- The Preoperative Treatment of Severely Anemic Patients with a Perfluorochemical Oxygen-Transport Fluid, Fluosol-DANew England Journal of Medicine, 1982
- Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroids prophylaxisBlood, 1982
- Clinical Studies of A Perfluorochemical Whole Blood Substitute (Fluosol-DA)Annals of Surgery, 1982
- Studies of endotoxin-induced decrease in lipoprotein lipase activity.The Journal of Experimental Medicine, 1981
- Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.Proceedings of the National Academy of Sciences, 1981
- Clinical Use of a Blood SubstituteNew England Journal of Medicine, 1980
- EndocytosisAnnual Review of Biochemistry, 1977
- Thyroid Allograft Immunogenicity Is Reduced After a Period in Organ CultureScience, 1975
- Determination of perfluorochemicals in organs and body fluids by gas chromatography.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975
- Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric PressureScience, 1966