Our present studies have been concerned with adrenaline and N,N-dimethyl-p-phenylenediamine (a derived pyridopyrimidine; DPP) oxidation by serum from patients with mental illness as compared with that of serum from normal controls and patients with nonspecific illness (i. e., without psychoses) who were shown to have high globulin levels in association with a variety of disease processes. Earlier work from this laboratory has demonstrated that in a statistically significant number of instances adrenaline oxidation in vitro proceeds more rapidly in the presence of serum from acute schizophrenic patients than it does in the presence of serum from normal controls.1,2In addition, it has been shown that the copper-globulin, ceruloplasmin, is the enzyme in serum which catalyzes adrenaline oxidation.3Recently Akerfeldt4has reported that the in vitro oxidation of DPP occurs sooner in the presence of serum from schizophrenic patients than in the presence of serum from