Steady-State Carbamazepine Plasma Concentration-Dose Ratios in Epileptic Patients

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Abstract
The distribution of carbamazepine plasma concentration-dose ratio was studied in 322 samples from patients undergoing long term treatment. Data have been grouped according to: (a) age — 3 to 6, 7 to 9, 10 to 14, and above 15 years old; (b) number of drugs used in the treatment — mono- and polytherapy; (c) dose — ⩽ 10, 10.1 to 14.9, 15 to 19.9, and ⩾ 20 mg/kg; and (d) plasma concentration found — < 4, 4 to 8, 8.1 to 12, and > 12 mg/L. From the results it is concluded that the carbamazepine concentration-dose ratio increases with age in children, but is less than in adults, is higher in monotherapy than in polytherapy, and decreases as the dose increases.