Peanut Agglutinin Inhibits Proliferation of Cultured Breast Cancer Cells

1 January 1988

journal article
research article
Published by S. Karger AG in Oncology

Vol. 45 (1) , 47-50
https://doi.org/10.1159/000226529

Abstract

Cultured breast cancer cells express on their surface glycoproteins which are recognized by the peanut lectin (PNA). The proliferation of these cells (ZR-75.1 and 734-B) was inhibited by PNA. A mammary carcinoma cell line (BT-20) which does not react with PNA was not affected by this lectin. The combination of PNA with either retinoic acid or 4-hydroxy-tamoxifen led to an additive amplification of the antiproliferative activity. Also interferon-γ showed in combination with PNA an improved growth-inhibitory action.

Keywords

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