Dissolution Testing of Ibuprofen Tablets

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Abstract
Dissolution testing (using three different methods, USP, FDA and a suggested method) was performed on eight different brands of commercially available ibuprofen tablets as purchased and also after storage at 37 C and 75% Relative humidity. Two dissolution values were determined at time 15 and 30 minutes. Statistical interpretation was performed using a Student's t test and Duncan multiple range test with an ANOVA on a SAS program. Some batches tested, notably, sugar coated tablets appeared to be particularly sensitive to the storage conditions used in this study and concern may be felt about possible loss of clinical efficacy. Of the three dissolution testing methodologies, the present USP method was the least discriminating, the FDA method was intermediate and the new proposed method was the most discriminating.