The reproducibility and sensitivity of visual evoked potential testing in rabbits

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Abstract
To examine the reproducibility and sensitivity of flash visual evoked potential (VEP) testing in rabbits, we recorded the VEPs elicited by light stimuli in conscious rabbits from an active electrode placed on the primary visual cortex. We analyzed flash VEPs of rab-bits by detecting the first negative peak, which was designated N 1.We evaluated the effects of dark adaptation time (from 5 to 30 min) on the latency and amplitude of N 1, and the coefficient of variation (CV) of these parameters. Then, the intensity of photopic stimulation was varied using a neutral density (ND) filter from the standard 0.6 J to its -1.8 log unit energy level at 0.3 log unit decrements. The N 1 latency and amplitude were measured at each recording. There was no significant change in VEP latency or amplitude when the dark adaptation time was varied from 5 to 30 min (n = 7, P > 0.05, ANOVA). The CV of the N1 latency was 0.4% and that of the N1 amplitude was 4.2% (n = 6). The N1 peak latency was prolonged and its amplitude de...