Asymmetric synthesis of the enantiomers of the diarylcarbinol (1R)- and (1S)-1-(1-hydroxyphenylmethyl)-2-hydroxybenzene
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 251-252
- https://doi.org/10.1039/c39950000251
Abstract
(1S)-1-Phenethyl(phenyl chromium tricarbonyl) ether (–)-4 undergoes completely stereoselective ortho-deprotonation with the thus formed carbanion being converted by the complementary sequences, benzoylation/hydride reduction and formylation/PhMgBr addition, to generate after decomplexation and deprotection the homochiral diarylcarbinols (–)-(1R)- and (+)-(1S)-1-(1-hydroxyphenylmethyl)-2-hydroxybenzene 1, respectively.Keywords
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