Studies on pleuromutilin and some of its derivatives.
- 1 January 1976
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (2) , 132-139
- https://doi.org/10.7164/antibiotics.29.132
Abstract
A number of derivatives of pleuromutilin (I) and of its degradation product, mutilin (II1, was prepared. The new monotosylation product of pleuromutilin (IIIc) served as the key substance for modification of the glycolic acid side chain. From the pleuromutilin monosuccinate (IIIk) water-soluble salts were obtained, among them the crystallized diethylaminoethanol salt that was investigated more closely. Some of the pleuromutilin derivatives showed antimicrobial activity.Keywords
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