Studies on the Experimental Epidemiology ofRespiratory Infections VIII. Experimental Pneumonic Plague in Macacus Rhesus

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Abstract
Pneumonic plague infection in monkeys was induced by exposing the animal to aerosols of Pasteurella pestis. The LD50 for the 139 strain of the organism was found to be about 20,000 inhaled cells. Clinical and laboratory finds in infected animals are presented. Neither living avirulent P. pestis, formalin-killed virulent P. pestis nor its antigenic envelope substance were effective as immunizing antigens, as judged by subsequent challenge to aerosols of the organism. Streptomycin therapy, effective at doses of about 5 mg/lb./day, was ineffective at 1.5 mg dosages in immunized or control animals.