Abstract
The nail is made up of a dorsal, intermediate and ventral zone - each with its own embryological origin. They were differentiated histologically and histochemically by their different staining properties (basophilia - neutral mucopoly-saccharides-sulphydrile and disulphide groups). These differences are due to the presence at each level of special "keratin-polysaccharides When applied to nail pathology, these histochemical techniques show modifications in staining affinities which correspond to changes in the physico-chemical structure of the nail keratin. In the onychomycoses, histochemical techniques are particularly valuable as much for detection as for experimental study.