Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase
- 21 August 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 44 (19) , 3195-3198
- https://doi.org/10.1021/jm010894d
Abstract
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3−100 μM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease β-amyloid deposition.Keywords
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