Differential Effects of D 600 on Contractile Response of Aorta and Portal Vein from Spontaneously Hypertensive Rats
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 18 (3) , 120-127
- https://doi.org/10.1159/000158344
Abstract
To examine if Ca handling by vascular smooth muscles is altered in hypertension, the in vitro effect of D 600 was determined on noradrenaline-induced contractions of aortic and portal vein strips from spontaneously hypertensive rats (SHR) and Wistar Kyoto normotensive rats (WKY). In low (0.2 and 0.4 mM) Ca solutions, D 600 reduced the response to noradrenaline to a greater extent in aortic strips from SHR than in strips from WKY. In contrast, D 600 had less effect on the response to noradrenaline in portal vein strips from SHR than in strips from WKY in both normal and low Ca. Thus, portal veins from SHR are less dependent on external Ca compared to portal veins from WKY whereas aortae from SHR are more dependent on external Ca compared to aortae from WKY.Keywords
This publication has 4 references indexed in Scilit:
- Hydralazine Prevents Changes in the Contractile Response of Aortic but Not Portal Vein Strips in Hypertensive RatsJournal of Vascular Research, 1980
- Contractility, Muscle Mass and Agonist Sensitivity of Isolated Portal Veins from Normo‐ and Hypertensive RatsActa Physiologica Scandinavica, 1977
- Contractile Responses to Noradrenaline: Varying Dependence on External Calcium of Consecutive Vascular Segments of Perfused Rat HindquartersActa Physiologica Scandinavica, 1977
- Quantitative Effects of External Calcium Concentration on Contraction of Rat Portal Vein Compared to Thoracic AortaActa Physiologica Scandinavica, 1976