Mutagen-directed Attenuation of Rift Valley Fever Virus as a Method for Vaccine Development

1 October 1985

journal article
Published by Microbiology Society in Journal of General Virology

Vol. 66 (10) , 2271-2277
https://doi.org/10.1099/0022-1317-66-10-2271

Abstract

Summary Serial mutagenesis with 5-fluorouracil has been employed to derive an attenuated strain of Rift Valley fever virus for use as a live virus vaccine.

Keywords

RVF VIRUS
BUNYAVIRIDAE
ATTENUATION