DISCRIMINATIVE STIMULUS PROPERTIES OF ANALGESIC DRUGS - NARCOTIC VERSUS NON-NARCOTIC ANALGESICS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 220  (2) , 329-332
Abstract
Using a food-reinforced 2-lever operant procedure, rats (no. = 6) were trained to discriminate fentanyl (1.25 mg/kg, p.o. [by mouth], t -60'') from solvent (1 mg/100 g B.W. [body wt] p.o., t -60''). The administration of another narcotic analgesic (pethidine) produced a dose-related generalization with the standard fentanyl treatment; 6 non-narcotic analgesics (suprofen, acetylsalicylic acid, indomethacin, phenacetin, phenylbutazone, tolmetin) did not do so. The ability of drugs to produce analgesia is not a sufficient condition for the drugs to produce the narcotic cue as well.

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