INDUCTION OF TUMORS IN RANA-TEMPORARIA WITH NITROSAMINES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 24  (3) , 249-251
Abstract
Dimethylnitrosamine (DMNA) and diethylnitrosamine (DENA) dissolved in tank water in a dose of 5 and 50 ppm, respectively, induced tumors of liver (hepatocellular cancers and adenomas), and hematopoietic system (hemocytoblastosis). DMNA induced neoplasms in 19 of 43 frogs (44.2%) the average latent period being 18.2 wk, while DENA induced tumors in 41 of 94 animals (43.6%) within a mean latent period 19.7 wk. Results of this investigation show the possibility of using anuran amphibians in short-term experiments in the study of nitroso compound carcinogenicity as well as a biological indicator for environmental pollution.

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