2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands

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Abstract
The synthesis and receptor-binding profiles at adenosine receptor subtypes for a series of 2-(arylaklyamino)-adenosin-5''-uronamides is described. Halogenated 2-phenethylamino analogues such as a 3e show greater than 200-fold selectivity for the A2 receptor subtype on the basis of rat brain receptor binding. The general structure-activity relationship of this series of compounds is discussed both in terms of potency at A2 receptors as well as receptor subtype selectivity. It is possible to introduce a hydrophilic carboxyalkyl substituent to this series such as in CGS 21680A (3h) and still retain good potency and selectivity for A2 receptors. In addition, functional data in a perfused working rat heart model shows that these compounds possess full agonist properties at A2 receptors with 3 h having a greater than 1500-fold separation between A2 (coronary vosadilatory) and A1 (negative chronotropic) receptor mediated events.