A MONOCLONAL ANTIBODY DETECTING A NEW HUMAN T CELL ANTIGEN, HULY-M2
- 1 August 1984
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 38 (2) , 143-147
- https://doi.org/10.1097/00007890-198408000-00010
Abstract
HuLy-m21 is a new T cell antigen detected by a monoclonal antibody. The antibody (anti-HuLy-m2) reacts with 85% of human T cells, 20% B cells and 50% null cells in peripheral blood. The antibody is cytotoxic, binds protein A and is of the IgG2a subclass. HuLy-m2 antigen consists of a glycoprotein dimer MW 37,000 subunit structure, in which sialic acid and carbohydrate play some role in antigenicity. Capping studies showed the HuLy-m2 antigen to be distinct from the previously described OKT-3, 4, 8, HuLy-m1 (OKT11) and HuLy-m3 antigens.Keywords
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