STUDIES ON PERITONITIS

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Abstract
Attempts have been made to produce experimental peritonitis by the intraperitoneal injection of bacteria into rabbits (Wegner,1Benians2and others) and into dogs (Noetzel3). The results have been conflicting, some investigators reporting rapid death; others, survival of the animals. The discrepancy is probably due to the variability in the numbers, type and pathogenicity of the organisms used as well as to the nature of the fluid employed in the suspension of the bacteria. Later work has shown that the intraperitoneal injection of relatively large quantities of broth cultures of virulentBacillus coliwill kill rabbits quickly without inducing severe peritoneal reaction (Steinberg and Ecker4). The same applies to guinea-pigs and to rats (unpublished experiments—Steinberg). This study was undertaken to determine the conditions necessary for the production of fatal peritonitis in the dog by the intraperitoneal injection of bacteria. EXPERIMENTAL WORK The micro-organism used in this investigation was a strain of

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