NITROGEN METABOLISM IN HYPERTHYROIDISM1

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Abstract
Subcut. daily injs. of synthetic (d-l) thyroxin produce a disturbance in nitrogenous metabolism, as evidenced not only by an increased total N output in the urine and a marked creatinuria and reduction of preformed creatinine but also by pronounced increases in ammonia and uric acid excretion and by an appreciable reduction in the excretion of allantoin. Thyroxinized animals show a marked retention of blood uric acid. The marked reduction of muscle and heart creatine in hyperthyroidism cannot be prevented by massive doses of vit. A or ascorbic acid. Subcut. injs. of glycine are followed by small increases in urinary excretion of preformed creatinine and significant increases in excretion of creatine, but glycine will not prevent the great losses of creatine from the muscles and the myocardium.

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