Prevention and Treatment of Motion Sickness by Intranasal Medication

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Abstract
Scopolamine in small doses (0.3-0.4 mg) given intra-nasally by spray 30 minutes prior to exposure, exerted significant protection against swing sickness. During actual flight testing addition of a surface active agent (sodium lauryl sulfate-Duponol C) increased its effectiveness. Nasal instillation to subjects 15-20 minutes after take-off sharply reduced the incidence of vomiting from airsickness during subsequent 40-45 minutes. Oral and sublingual administration under these conditions were ineffective. Considerable variations in the drug instilled resulted when given by spray. The use of nose drops allowed more accurate medication. The significance of this mode of administration for treating motion sickness is discussed.

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