Permeability Changes Produced in Mice by Bordetella pertussis

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Abstract
Summary: Various methods of demonstrating permeability changes produced in mice by B. pertussis were described. By measuring the amount of Evans blue that disappears from the circulation it was found that the increased permeability of capillaries can be demonstrated 1 day after the injection of B. pertussis and persists for at least 8 days. By the end of 16 days after the injection of B. pertussis, the permeability to Evans blue had returned to normal. A good correlation was found between permeability changes and the increased histamine sensitivity in B. pertussis-treated mice, although S. enteritidis endotoxin or B. pertussis endotoxin, which produce permeability changes as marked as B. pertussis cells, failed to increase the sensitivity to histamine. Adrenalectomy also increased the permeability of capillaries to Evans blue. The increase in permeability produced by B. pertussis could be prevented by pretreatment of mice with hydrocortisone. S. enteritidis endotoxin did not increase the susceptibility of mice to passively induced anaphylaxis, although it seems to have some enhancing effect on actively induced anaphylactic sensitization. The significance of these results is discussed.

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