Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells.
Open Access
- 6 January 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 91 (1) , 37-45
- https://doi.org/10.1093/jnci/91.1.37
Abstract
Activation of the enzyme telomerase, which has been associated with cellular immortality, may constitute a key step in the development of human cancer. Telomerase is repressed in most normal human somatic cells. This study was conducted, using a genetic complementation approach, with the aim of identifying and mapping the genes responsible for repressing telomerase and, simultaneously, to establish the effect of experimentally induced telomerase repression on human tumor cell growth.Keywords
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