Effects of Sensitization on the Permeability of Urothelium in Guinea Pig Urinary Bladder

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Abstract
Permeability of the guinea pig urinary bladder was investigated in a model of experimental cystitis indueed by intravesical antigen challenge following sensitization. Guinea pigs were sensitized by intraperitoneal injections of ovalbumin (10 mg./kg.) given on days 1, 3, and 5. The studies described were done four weeks after the last injection. Controls (injected with saline) were used at the same time as sensitized animals. Each group (control and sensitized), was divided into two subgroups; guinea pigs challenged with intravesical ovalbumin (10 mg./ml., one ml.) and those receiving one ml. saline intravesically. Immediately following the antigen (or saline) challenge, one ml. of14C-urea was placed into the bladder for two hours.