VASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE NORMOTENSIVE AND HYPOTENSIVE RATS
Open Access
- 1 February 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 50 (2) , 185-188
- https://doi.org/10.1111/j.1476-5381.1974.tb08560.x
Abstract
1 Three strains of rats spontaneously hypertensive (HRS), normotensive (NS) and hypotensive (HOS), were selected by repeated inbreeding. 2 In order to explain the different blood pressure levels observed, we have studied their vascular reactivity to noradrenaline and angiotensin II. Experiments were performed in anaesthetized ganglion-blocked, vagotomized rats. 3 The reactivity to noradrenaline was significantly higher in HRS than in NS and HOS rats. 4 The reactivity to angiotensin II appeared identical in the three strains used.Keywords
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