Ganglion Blocking Effect of Indole Alkaloids contained in Uncaria Genus and Amsonia Genus and Related Synthetic Compounds on the Rat Superior Cervical Ganglion in Situ

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Abstract
Effects of some standard drugs, indole alkaloids contained in Uncaria Genus and Amsonia Genus and several related synthetic compounds on transmission were examined in the rat superior cervical ganglionic preparation in situ. In this preparation, standard drugs could produce typical actions to be expected. It was confirmed that this preparation could be routinely used and an arterial injection of drugs was preferable in order to examine their direct action on the ganglion. All indole compounds, administered arterially, showed a ganglion blocking action except one. Among these, hirsutine, 2, 3-seco-yohimbine, I and V exerted a relatively strong inhibitory effect comparable with that of hexamethonium.

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