Enantioselective Epoxidation of Chromene Derivatives Using Hydrogen Peroxide as a Terminal Oxidant

1 January 1994

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1994 (04) , 255-256
https://doi.org/10.1055/s-1994-22817

Abstract

Hydrogen peroxide was found to serve as an effective terminal oxidant for the salen-catalyzed asymmetric epoxidation of chromene derivatives, when N-methylimidazole was added to the reaction medium. Under the conditions, 6-acetamido-2,2-dimethyl-7-nitrochromene was converted into the corresponding epoxide of 95% ee in 98% yield.

Keywords

EPOXIDATION
CHROMENE DERIVATIVES
TERMINAL OXIDANT
HYDROGEN PEROXIDE
ACETAMIDO
SALEN
CONVERTED

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