Trauma as a Cause of Localization of Blood-Borne Metastases

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Abstract
The number of metastases in the area of local trauma due to injection of turpentine was greatly increased following intra-aortic injection of Walker 256 carcinosarcoma cells in the rat. When the animals, injected with turpentine before tumor cell infusion, were treated with heparin or fibrinolysin: 1) the incidence of bilateral leg metastases was greatly reduced, 2) metastases in the traumatized leg were decreased, though less than with the bilateral leg and hepatic metastases; 3) hepatic metastases were reduced significantly; and 4) survival for nine weeks without obvious tumor was increased 5 to 6 times.