The Hypoprothrombinemia-Inducing Activity of Link’s Compound #63 (Methopyranorin)

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Abstract
Methopyranorin is 2-3 times as potent as dicumarol in its hypoprothrombinemia-inducing activity. Vit. K and fresh blood transfusion counteract the effect of the drug, as with dicumarol. The hemorrhage producing capacity of the drug appears to be at least not greater than that of dicumarol and has a high degree of predictability of response. By virtue of its pronounced and prolonged hypoprothrombinemia-inducing activity, it is particularly well-suited for anti-thrombotic treatment by the intermittent dosage method. By properly spacing the doses it is possible to maintain a patient for 1 mo. by giving 3 doses. The advisability of administering mixtures of the available oral anticoagulants is discussed.