Chemistry of nitrosoureas. Decomposition of deuterated 1,3-bis(2-chloroethyl)-1-nitrosourea
- 1 July 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (7) , 958-961
- https://doi.org/10.1021/jm00229a019
Abstract
BCNU-.alpha.-d4 [1,3-bis(2-chloro-1,1-dideuterioethyl)-1-nitrosourea] and BCNU-.beta.-d4 [1,3-bis(2-chloro-2,2-dideuterioethyl)-1-nitrosourea] were synthesized and decomposed in buffered (ph 7.4) water. The products were analyzed by gas chromatography-mass spectra. The deuterium distribution in the products was inconsistent with vinylcarbonium ion or diazochloroethane intermediacy but was consistent with a 2-chloroethylcarbonium ion intermediate with some rearrangement to the 1-chloroethylcarbonium ion and the cyclic chloronium ion.This publication has 2 references indexed in Scilit:
- The Modes of Decomposition of 1,3-Bis(2-chloroethyl)-1-nitrosourea and Related CompoundsJournal of Medicinal Chemistry, 1967
- The Synthesis of Antineoplastic Agents. XXXII. N-Nitrosoureas.1 I.Journal of Medicinal Chemistry, 1963