Abstract
By the use of the acid phosphatase method, neuronal dysfunction and degeneration were studied. The signs of disintegration can be noticed as early as 5 days in the axons of the pyramidal tract of the monkey following cortical extirpation . The disappearance of acid phosphatase from all pyramidal axons is rather complete by the 15th postoperative day. It was found that the larger the axon the more quickly the enzyme disappeared following maximal injury.