Unexpected formation of O-methoxycarbonyl cyanohydrin showing potential as a protective group of ketones
- 1 September 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (9) , 1423-1425
- https://doi.org/10.1055/s-1999-2859
Abstract
A one-step procedure using methyl cyanoformate and a secondary alkylamine was reported to efficiently transform ketones into O-methoxycarbonyl cyanohydrins. This functional group shows interesting potential in protecting group chemistry.Keywords
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