POTENTIATION OF CYTOTOXIC ACTION OF MELPHALAN AND ACTIVATED CYCLOPHOSPHAMIDE AGAINST CULTURED TUMOR-CELLS BY CENTROPHENOXINE
- 1 January 1977
- journal article
- research article
- Vol. 200 (1) , 17-24
Abstract
Centrophenoxine, without antitumor activity itself, enhanced the cytotoxic action of melphalan and activated cyclophosphamide against mouse P388 lymphoma and rat Walker 256 carcinosarcoma cells growing in static suspension culture. The concentration of alkylating agent required for 99% cell kill was approximately halved when centrophenoxine was also present during exposure to the antitumor drug. Maximum potentition by centrophenoxine of the cytotoxic action of melphalan occurred when cells were exposed to the 2 agents simultaneously. Little or no potentiation was observed when cells were exposed to centrophenoxine before or after exposure to the alkylating agent.This publication has 1 reference indexed in Scilit:
- Differences in the response of leukaemia cells in tissue culture to nitrogen mustard and to dimethyl myleranBiochemical Pharmacology, 1961