Effect of lymphocytosis-promoting factor from Bordetella pertussis on cerebellar cyclic GMP levels
- 1 June 1982
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 36 (3) , 958-961
- https://doi.org/10.1128/iai.36.3.958-961.1982
Abstract
Dermonecrotic toxin (DNT), lipopolysaccharide (LPS), and lymphocytosis-promoting factor (LPF) were isolated from Bordetella pertussis and tested for neuroactivity. When injected intraperitoneally into rats, a dose of 0.13 mg of LPF per kg elevated the cyclic GMP level in cerebellum by approximately 70%, whereas DNT (0.5 mg/kg) and LPS (1.5 mg/kg) were without effect. This action of LPF on the central nervous system was dose dependent and did not require the administration of any additional agent, such as histamine.This publication has 23 references indexed in Scilit:
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