Effects Of Certain Organisms Associated With Chronic Respiratory Disease On Spf And Conventional Rats

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Abstract
Most of a series of 16 conventional rats examined at various ages were found to have Streptobacillus moniliformis and Mycoplasma pulmonis in the nasopharynx and sometimes also in the lungs. Fifteen of the rats had histological evidence of chronic respiratory disease (CRD). Specific-pathogen-free (SPF) rats of the same strain, but kept in isolation, did not appear to carry these infections and had no histological evidence of CRD.

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