Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs

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Abstract
Plasma insulin-like growth factor I concentrations from proportionate, chondrodystrophic and giant breeds were evaluated and compared with body size. IGF-I plasma concentrations were 91.2 .+-. 10.9 .mu.g/l in Keeshounds (proportionate dog), 122.6 .+-. 25.4 .mu.g/l in Bassethounds (chondrodystrophic dog) and 280 .+-. 22.8 .mu.g/l in German Shepherds (proportionate dog). The highest IGF-I level (389.6 .+-. 24.2 .mu.g/l) was found in the New Foundland, a giant breed (mean .+-. SEM). The mean body weight was 11.8 .+-. 0.4 kg in Keeshounds, 15.4.+-. 1.4 kg in Bassethounds, 32 .+-. 1.5 kg in German Shepherds, and 45.6 .+-. 1.7 kg in New Foundlands (mean .+-. SEM). Body weight and plasma IGF-I concentration were significantly correlated (.gamma. (IGF-I) = -7.43 + 8.7 .times. (body weight); P < 0.0001).