ROLE OF TRACE-METALS IN CALCIUM UROLITHIASIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 14  (5) , 347-350
Abstract
Ten urinary stones composed of calcium oxalate or a mixture of calcium oxalate and calcium phosphate were analyzed for trace metal content by emission spectroscopy. Trace metals found in amounts of 0.001% or more were Fe, Cu, Zn, Sn, Pb and Al. The inhibitory effect of each of these trace metals on the crystal growth of calcium oxalate and calcium phosphate was tested. None of the metals affected the crystal growth of calcium oxalate at concentrations approximating those found in normal urine. The metal ions Cu (II), Zn (II), Sn (II) and Al (III) did affect the crystal growth of calcium phosphate when present at physiologic concentrations; their contribution to the total calcium phosphate inhibitor activity in urine was estimated to be insufficient to have a regulatory role in urinary stone growth.

This publication has 1 reference indexed in Scilit: